Although instances of discrimination are increasing across US schools, little is known about the relations of discrimination to mental health outcomes across the full range of school ages or how experiences of discrimination interact with various sociodemographic characteristics. This study entailed analysis of data from approximately 60,700 respondents to the 2011-2012 National Survey of Children's Health to explore the associations between racial/ethnic discrimination and depression, anxiety, oppositional defiant disorder, and conduct disorder for children and youth ages 6-17. Multivariate logistic regression indicated that experiencing racial discrimination was associated with significantly increased odds of having a range of mental health problems including depression, anxiety problems, and behavior disorders. Moreover, an interaction effect was observed between discrimination, race, and anxiety. No interactions were observed for variables related to age groupings. Implications for school-based mental health practitioners and researchers are discussed.