The purpose of this study was to investigate university instructors' knowledge of and experience with misophonia, including whether instructors would make classroom accommodations typically requested by students with misophonia. Misophonia is a sound tolerance disorder, that is characterized by an oversensitivity to certain sounds which can result in the distraction of the person that may limit one's ability to concentrate, think, and learn. Qualitative data were collected using a survey sent by email to undergraduate instructors at six institutions in the state of Florida. A total of 686 participants completed the survey and were asked to define misophonia. Another set of ten questions was completed using a five-point Likert scale. Statistical analyses included inferential analysis of mean scores and principal components analysis. Only 18.4% of participants self-reported having knowledge of misophonia and only 2.3% reported that a student had requested accommodations in their course(s). Instructors who indicated knowledge of misophonia agreed that this is a condition to be taken seriously more often than those without knowledge of misophonia. Instructors who had experienced a student disclosure indicated that, with official accommodation, they would be willing to use proctored exams more often than those without experience of a student disclosure. The findings of this survey indicate that dissemination of information on the topic of misophonia is critical, both for educators and for students.