Advances in the field of neuroscience can be used to support scientific research and best practices in the profession of art therapy. This article provides a general overview of how neuroscience informs art therapy by providing an overview of neuroscience research in art therapy and offering practical applications for adopting a neuroscience-informed way of working. Integrating neuroscience research into art therapy practice entails having a clear rationale for one's practice and when sharing didactic information with clients can aid treatment goals.