This systematic review summarizes the extant literature concerning college students and alcohol mixed with energy drink (AmED) consumption. Inclusion criteria incorporated studies that reported on AmED consumption, along with attitudes and perceptions of energy drink and AmED use among United States college students ages 18-25. The search yielded 35 articles published after 2007. For the majority of studies, response rates and validity measures were not included. Researchers overwhelmingly relied on convenience samples, self-reported data and single-site samples. Most measured consumption patterns and associated consequences, while a few were based on a health behavior theory. Future research must report response rates and results from psychometric testing of measurement tools. The use of randomized sampling methods with more heterogeneous samples is also recommended.