The study tested the relationships between personality, grit and grade point averages (GPAs) among university students. The sample was 406 undergraduate students (299 females and 107 males) from three universities in Istanbul. The instruments used in the study were Grit-S and the Big-Five Inventory. The data were analysed through a path analysis. The results of the path analysis for the first model exploring the relationship between personality and GPA through the mediating role of grit showed that the model did not seem sufficiently applicable for the data. In the second model, grit and neuroticism were determined as independent variables predicting GPA, whereby it seemed that conscientiousness mediated this relationship. The results for the second model showed that the neuroticism has significantly negative relationship with grit; grit has significantly positive relation to conscientiousness and conscientiousness has a significantly positive relationship with GPA.