Education decision makers routinely make choices among programs and strategies to implement. Policy demands increasingly require that such decisions are based on evidence regarding program effectiveness at improving student outcomes. However, research evidence is but one of the considerations that practitioners must juggle, along with local conditions, capacity, resource availability, and stakeholder values. We investigated the feasibility of applying a multicriteria decision-making framework based on cost-utility analysis to facilitate evidence-based decisions by educators. Working with a total of 183 aspiring school leaders in class settings, we determined to what extent they could implement the initial steps of the framework. We subsequently invited three educators to apply the full framework to substantive decisions in their schools and report the results.