This study examined the effect of sample size ratio and model misfit on the Type I error rates and power of the Difficulty Parameter Differences procedure using Winsteps. A unidimensional 30-item test with responses from 130,000 examinees was simulated and four independent variables were manipulated: sample size ratio (20/100/250/500/1000); model fit/misfit (1 PL and 3PLc = 0.15 models); impact (no difference/mean differences/variance differences/mean and variance differences); and percentage of items with uniform and nonuniform DIF (0%/10%/20%). In general, the results indicate the importance of ensuring model fit to achieve greater control of Type I error and adequate statistical power. The manipulated variables produced inflated Type I error rates, which were well controlled when a measure of DIF magnitude was applied. Sample size ratio also had an effect on the power of the procedure. The paper discusses the practical implications of these results.