The aim of this study was to investigate the impact of being away from home on the well-being of international and domestic UK university students as a function of demographic factors, course load, support, personality, healthy lifestyle, and their employment of pre-planning and being at university strategies. A total of 510 students (n = 391 international and 117 British) completed an on-line survey to record demographic details and measure their well-being, quality of university life, and their being away from home strategies. The findings showed that International students reported greater quality of university life and used more pre-departure strategies; the female students reported a significantly more negative well-being and higher course demand than their male peers. A regression analysis showed that positive well-being was predicted by a positive personality, a healthy lifestyle, control and support for academic work, quality of university life and employing well-being strategies (using technology without over-reliance on it and the ability to unwind from study). Negative well-being, on the other hand, was predicted by a less positive personality and a less healthy lifestyle, a higher course demand, less control and support for academic work and less quality of university life. Moreover, the regression analysis showed that international students who employed more pre-departure strategies showed less negative well-being.