The purpose of this study is to discuss the effects of visuals, visual literacy, visualization and multimedia design strategies using instructional design (ID) models for developing projects in education and science education, as well as engineering education. This study discusses and presents ways to evaluate visuals, visualization, and virtual technologies (as VR/AR and 2D-3D) in science education and engineering education based on research and foundations of visual learning, visual thinking, and visual communication. This study is a literature review work concerning visual effects, visual literacy, learner perceptions and technological variables for designing multimedia instruction and learning projects in visualization. In addition, this paper discusses similarities and constraints in using ID models for designing multimedia projects from the perspective of the use of visuals and ID models for developing visual materials in education. These procedures include the perceptual and theoretical foundations of visual learning, cognitive factors of visual images, visual design and program of systematic evaluation steps, as well as multimedia projects design and development materials with ID models, such as the decide, design, develop, and evaluate (DDD-E) model (Ivers, Barron, 2010) and a human information processing model (Mayer, 2001). With these models, all considerations for visual typology will be indicated in the implementation of visuals, learning design, visualization using virtual reality technologies and evaluation of visuals in multimedia development. Concluding the paper, meaningful connections between visuals and technological variables for developing multimedia project design will be considered. Indicators for learners and designers and teachers will be shown in learning imagery for visualization activity and educational technology. This will be followed by a discussion of the use of visuals and evaluation of visual materials based on the program of systematic evaluation developed by Dwyer (1972, 1978, 1987, 1994).