Infants who stay in emergency shelters with their families are most likely to demonstrate resilience despite homelessness if they experience positive, nurturing relationships with their parents. We discuss the strengths and challenges of infants experiencing family homelessness as well as intervention and research evaluation in those contexts. Next, we describe our collaborative efforts to implement and evaluate a unique parenting intervention, My Baby's First Teacher, which was designed specifically for supporting positive parenting for infants in shelters.