The misuse of alcohol and other drugs is a health concern for National Collegiate Athletic Association (NCAA) level student-athletes. NCAA Division II level student-athletes from a State-Supported Regional University (SSRU) were part of a CHOICES Grant program which aided the athletic department as it partnered with other campus departments in the development and implementation of alcohol and drug education projects. The American College Health Association National College Health Assessment IIb Survey (ACHA-NCHA IIB) was given to the SSRU's student-athletes. Two areas of health concern (high-risk drinking, nonmedical use of prescription drugs) were identified where improvements are necessary. The results supported the SSRU's goals as it continues implementing education and prevention programs based on collaboration among student-athletes, coaches, athletics staff, and prevention specialists.