Increasingly, leaders of youth-serving organizations voice concern about low Latinx participation (Borden et al., 2006), often recognizing that poor participation reflects a need to develop new capacities and inclusive practices (Perkins et al., 2007). The authors were asked to summarize the scholarship on Latinx participation in youth development programs and recommend ways to promote meaningful and sustained participation. This article presents key elements of this research synthesis. The goal of the paper is to help out-of-school time (OST) programs develop concrete, research-based, context-responsive approaches to improving Latinx participation. First, the authors elaborate on the importance of Latinx youth participation in OST activities and present the framework that guided their analysis of the literature. After outlining their methodology, they then summarize the key themes in the literature and articulate strategies for developing high-quality OST programs with sustained high Latinx participation. The conclusion poses questions for OST practitioners to facilitate critical reflection and thoughtful planning for inclusion of Latinx youth.