This study aims to explore how the tourism and hospitality department promotes the influence of teachers' knowledge innovation on students' creativity self-efficacy and innovation behaviors. Taking teachers and students in tourism and hospitality departments of 30 universities and colleges in Taiwan as subjects and analyzed by hierarchical linear modeling. It is found that knowledge application of teachers' knowledge innovation has positive moderation effect on students' creativity self-efficacy and students' innovation behaviors. Knowledge generation has negative moderation effect on students' creativity self-efficacy and students' innovation behaviors. However, teachers' knowledge innovation does not influence students' innovative behavior. Their knowledge innovation will influence students' innovative behavior on the premise that the interaction effect of lecturers' knowledge innovation and students' self-efficacy happens. Therefore, university and college should value and increase students' innovation self-behaviors and properly plan teachers' knowledge innovation to help students on innovation behavior performance and development.