Information communication technologies (ICT) is increasingly being introduced in the preschool level, but questions have been raised regarding its potential to develop content knowledge or specific skills. This quasi-experimental study looked into the impact that hand-held tablets can have on science learning outcomes in five-year-olds. Four classes from two preschool institutions in Buenos Aires, Argentina, were selected for a six-week intervention. All four classes received training and an inquiry-based science teaching sequence, with one group from each institution also receiving tablets and specific guidance on how to incorporate them into their science lessons. Post-intervention test results showed significant improvements in science outcomes for all students, but no significant difference between the tablet-enhanced classrooms and those taught without ICT. Challenges and opportunities are discussed with regard to including tablets for teaching science at the preschool level.