The purpose of this article was to examine the effects of strengths-based approaches in co-curricular and curricular leadership on first-year students' holistic thriving, academic thriving, social thriving, and psychological thriving. We used propensity score matching and regression analyses with survey data from the Thriving Quotient, which was administered to first-year students at a large, public research university (n = 548). The results suggest students' enrollment in a strengths-based leadership minor course was associated with higher levels of thriving in social, academic, and psychological domains. Students' participation in strengths-based student organizations was associated with higher thriving in social domains, while concurrent enrollment in the strengths-based leadership class and participation in strengths-based student organizations was associated with significantly higher holistic thriving, social thriving, and psychological thriving.