Vocational and Technical Education (VTE) plays a vital role in national development, such that many great nations make it an essential part of their policies and invest in its curriculum. Its role in national development warrants the need to conduct studies on it. Thus this study is on comparative analysis of vocational and technical education at the senior secondary school level in Nigeria and Ghana. Integrated research method was employed in the study involving Historical, Scientific and Comparative methods. It was found that the philosophy and objectives of VTE at the senior secondary school level are good in Nigeria and Ghana; implementation of the curriculum content is better in Ghana than in Nigeria; administration and funding of VTE are better in Ghana than in Nigeria. It was concluded that there is need for improvement of VTE more in Nigeria than Ghana and recommendations are made in that regard.