Since the advent of STEM (Science, Technology, Engineering and Math) programs, first in K-12 and now in college curricula, many variants of STEM have arisen to include other disciplines in developing cross-disciplinary literacy among students. This paper briefly defines our own variant STE[A]M branch within the context of cross-disciplinary teaching and learning and then describes an interdisciplinary course, The Science in Science Fiction, in which professors of Biology, English, and Physics provided a range of science fiction texts which undergraduate and graduate students studied and discussed in depth. Students then produced and presented collaborative cross-disciplinary research on topics of their choice from the course work. Finally, students provided input on their experiences with collaborative cross-disciplinary teaching and learning. The overall effect was extremely positive. This article provides a framework for other faculty who would like to model this approach.