This multiple case study investigated the impact of art therapy treatment on depressive symptoms in women diagnosed with infertility. A mixed-methods study design was implemented in which 13 participants each engaged in 6 individual art therapy sessions. The Beck Depression Inventory-II (BDI-II) was administered before and after the 6 sessions, and each participant engaged in a postintervention interview about her experience in art therapy. The pretest and posttest data from the BDI--II were compared and the qualitative interviews were analyzed to gain further insight into the full experience. Following the intervention, the levels of depression among the participants decreased significantly. Themes that emerged from the qualitative data described in depth participants' experiences with infertility and with art therapy.