This study investigated the mediation effect of locus of control and achievement motivation between academic stress and life satisfaction. A total of 307 undergraduate students recruited from a Hispanic Serving Institution in South Texas participated in the study. In the frame of the study, two mediation models were tested by utilising PROCESS Procedure for SPSS (Hayes, 2013. "Introduction to mediation, moderation, and conditional process analysis: A regression-based approach." New York, NY: Guilford Press). The results indicated that bivariate correlations among study variables ranged from -0.24 to 0.32. The overall composite indicated that academic stress contributed to 6% of the variance in life satisfaction (p < 0.01) among students (b = -0.06), while the mediating effect of locus of control contributed to 10% of the variance in Life Satisfaction (p < 0.01) among students (b = -0.4).