This study was designed to evaluate the effectiveness of a brief Alcohol Expectancy Challenge, with the aim of reducing the prevalence of alcohol consumption amongst Maltese teenagers.119 students were randomly allocated to a control or a 3-hour expectancy challenge session. Alcohol consumption and alcohol expectancies were investigated via a self-report questionnaire delivered at baseline, immediately after the intervention and at 4 months follow-up. Despite significant differences in alcohol expectancy scores at the post-intervention, no significant reductions in alcohol consumption were observed in the experimental group. On the other hand, a significant increase in alcohol consumption was observed in the control group at post-intervention. This study failed to support the effectiveness of alcohol expectancy challenge (AEC) to curb alcohol misuse, but it is still possible that AEC may help prevent the increase of alcohol consumption. Possibly, the teaching of alcohol refusal skills and educational efforts to help dispel prevalent misconceptions related to alcohol expectancies amongst both parents and students can yield more effective long-term outcomes. Targeting school children from an earlier age might also be needed since alcohol expectancies are often formed in childhood.