This article presents Culturally Responsive Positive Behavioral Interventions and Supports (CRPBIS), the first framework to operationalize cultural responsiveness in the context of positive behavioral interventions and supports in the United States (Bal 2011). To develop the CRPBIS framework, the author first conducted a systematic review of literature. Then, the author developed the CRPBIS framework based on the literature review and interdisciplinary literature from cultural psychology, organization studies, learning sciences, critical geography, cultural studies, as well as education research. Finally, to test and refine the framework in practice, a multisite, mixed-methods formative intervention study was conducted in the state of Wisconsin between 2012 and 2015 (Bal et al. 2014, 2016; Bal 2016, 2017; Bal, Afacan, and Cakir 2017; Bal, Afacan, and Clardy 2017).