This study investigates whether the Cognitive Acceleration through Science Education (CASE) scheme could be used to meet the demands of the Literacy and Numeracy Framework (LNF). The LNF is part of the Welsh Government's improvement strategy in response to perceived poor performance in the Programme for International Student Assessment (PISA) surveys by students in Wales. It reviews some research evidence for the approach and studies current use within North Wales. Finally, it suggests a way in which these principles could begin to be adapted within science lessons to meet the requirements of the LNF.