Objective: To examine the psychometric properties of a measure of cannabis-specific Protective Behavioral Strategies (PBS), which assesses ways in which students may reduce cannabis-related risk. Participants: Respondents to the American College Health Association-National College Health Assessment II (N = 580) during Spring 2015. Methods: Exploratory Factor Analysis (EFA) and Exploratory Structural Equation Modeling (ESEM) were used to identify and replicate the factor structure of the measure. Results: Results support a four-factor model (Respiratory Health, Frequency/Quantity, Socializing, and General Health) with close approximate fit (?[superscript 2] (310) = 565.96, p < 0.001, RMSEA = 0.038 (0.033, 0.043; 90% CI), CFI = 0.961, TLI = 0.929, SRMR = 0.033). Support for the convergent validity and construct validity of the measure was also found. Conclusions: This is the initial step in the development of a standard, psychometrically validated measure of cannabis PBS that has the potential to inform future research and interventions.