This research focuses on exploring the effects of game-based learning (GBL) and self-regulated learning (SRL) on promoting students' learning and the interactions between teachers, students and peers. The experiment designed for this study was conducted in the course of "Media Marketing Management". The effects of GBL, SRL, and their combination on the students' learning performances are analyzed with the quantitative and qualitative data of students' learning. Based on the results of this study, it is found that students who receive the combined teaching methods of web-mediated GBL and SRL have better learning performance than those receive traditional GBL in classroom, although insignificantly. Not only is the outcome of SRL and interactive learning improved, the efficiency of teaching is enhanced. The implications of this study are also discussed.