Background: Latino adolescents are a subpopulation of youth who are disproportionately at risk for experiencing low levels of hope, which is linked to high levels of anxiety. However, factors such as religion/spirituality (i.e., identifying as a spiritual/religious person), that may buffer this association are not yet clear. Religion/spirituality may serve as a protective factor in this link by fostering positive coping. Objective: The current study examined the moderating role of religion/spirituality the link between hope and anxiety in a sample of Latino youth. Religion/spirituality combined with high levels of hope was hypothesized to be associated with the lowest levels of anxiety. Methods: 134 Latino adolescents (83.5% Mexican heritage) attending a charter high school in a large Midwestern city (45.5% Male, M = 16.14 years, SD = 1.31) completed a survey that included items measuring religiosity/spirituality, beliefs around goal setting, and self-reported anxiety symptoms. Results: A link between hope and anxiety was evident, with higher levels of hope associated with lower levels of anxiety. However, religion/spirituality moderated the association between hope and anxiety. Simple slope plots revealed that a negative association between hope and anxiety was only evident in the presence of religion/spirituality. Hope was unrelated to anxiety in the absence of religion/spirituality. Conclusions: Findings did not support a buffering effect of religion/spirituality. Religious/spiritual coping may strengthen the link between high levels of hope and low anxiety levels in this sample.