In today's dynamic learning environment, educational delivery methods have become increasingly diverse. Using a unique opportunity to assess three types of course delivery--face-to-face, interactive television (iTV), and purely online delivery--the authors look at both initial knowledge acquisition and the retention of this knowledge. The results indicate that the online class outperformed the face-to-face and iTV sections on the initial performance evaluation; however, knowledge retention was greater in the face-to-face and iTV sections. The authors' findings suggest that diverse educational delivery methods provide unique benefits to students, but these benefits vary in relation to immediate learning outcomes and knowledge retention.