This chapter addresses how fundamental principles regarding how people learn in the last decade open up possibilities for conceptualizing a broad ecological culturally rooted framework for the design of robust learning environments in a variety of settings, especially schools. These cross-disciplinary principles emerging from across relevant disciplines run against the persistent metanarratives warranting inequitable educational and life course outcomes for youth in minoritized nondominant communities and those living in persistent poverty in deficit claims. This chapter synthesizes research findings from across cognition, human development, the neurosciences, and learning in academic disciplines to document emerging consensus around generative principles that can inform the design of robust learning environments.