The release of the IS2010 Model Curriculum has triggered review of existing Information Systems (IS) programs. It also provides an opportunity to replace low enrollment IS programs with flexible ones that focus on specific application domains. In this paper, the authors present a case study of their redesigned Computer Information Systems (CIS) program that comes into effect in Fall 2012. Of the four tracks in the program, two are aimed at students interested in two diverse application domains: Business Administration and Graphics Communications (Multimedia). The authors describe the context and design constraints in choosing the tracks, as well as the process used in designing their flexible CIS program with consideration made for ABET accreditation. They also discuss how well the core courses in the redesigned CIS program fare against the IS2010 Model recommendations. Further, for the CIS Business track, they illustrate how the courses collectively satisfy the IS Body of Knowledge recommended in the Model document. In addition, they map the domain-related courses in that track onto the different levels of a two-dimensional learning taxonomy to help design the assessments in those courses. They also provide an outline of the Multimedia track they developed using the same process.