This study aims to determine the influence of scientific approach based learning program (P2BPS) against generic science skills of students. The method used in this research is "quasi experiment" with "two-group pretest posttest" design.The population in this study were all students who take courses in general physics II at the Department of Physics Physics, Faculty of sciences State University of Medan. The sample was determined by random cluster sampling technique. One class as an experimental class taught by the scientific approach based learning program and the class as a class taught by conventional learning control. Data collection techniques using generic science skills test instruments. The results of data analysis showed that students taught with a scientific approach based learning program have better generic science skills than when taught by conventional teaching. It can be concluded that there is significant influence learning program based scientific approach to generic science skills of students in general physics course II.