This paper reports on research into a continuing professional development (CPD) project, "Projet de Renforcement de l'Enseignement des Mathématiques, des Sciences et de la Technologie" (PREMST) [Strengthening Mathematics, Science, and Technologies in Education Project]. The literature review reveals few examples of CPD changing the teaching practices of teachers, especially in sub-Saharan Africa. By using the cases of five teachers, this research seeks to understand the complexities of pedagogical change. The research found that PREMST has helped teachers envision how teaching should be conducted, but it has not necessarily brought a positive change in the learning of pupils because it has not changed how teachers think about teaching. Given the difficulties involved in pedagogical change, emphasising specific skills may have been the necessary and practical first step, but changing these teaching practices is not enough. The research found that teachers still paid little attention to the learning of individual pupils. The research concludes that the recently initiated practice of lesson study shows considerable potential to build on what has already been achieved.