Studies have shown that course organization and structure, student engagement, learner interaction, and instructor presence have accounted for considerable variance in student satisfaction and perceived learning in online learning environments through a range of pathways, although no research to date has tested the mediational relationship identified. This study expanded upon the existing literature about online learning and the variables that influence student satisfaction and perceived learning. The researchers investigated the relationships among course structure/organization, learner interaction, student engagement, and instructor presence on student satisfaction and perceived learning. The results of this study were intended to inform practice related to increasing retention and improving the quality of online teaching and learning.