While there is evidence of the growing popularity of iPads and other tablets in K-12 education, little is understood about how teachers use these devices in their instruction. This study examines 342 teachers' comfort level with and perception toward iPad use and any changes that occurred over the implementation year. Using a mixed-methods design, this study found significant differences in comfort level by years of teaching and school levels. Female teachers, teachers with 20 years or less of teaching experience, and elementary school teachers were more positive about their perception toward iPad use than the other groups. High school teachers' perception was the lowest overall. Analyses of teacher interviews revealed affordances, challenges, and diverse ways of how teachers used iPads in their instruction. Implications for practice and research are discussed.