The study examines the use of waste materials as instructional resources in teaching and learning Art lessons. Primary, Junior and Senior High School Art teachers in Ghana mostly teach their lessons without instructional resources because the government is not able to provide materials to create the needed resources. The study therefore explored local waste materials which create nuisance in the environment in Ghana to create appropriate teaching resources for Art in Ghana. This study shows differences in classroom atmosphere and student performance when instructional resources are used or not used in teaching and learning. The study adopted the exploratory, quasi-experimental and descriptive research methods. Art teachers from Kumasi were selected to teach with developed instructional resources after which lessons taught with and without the instructional resources were compared. The study found that when instructional resources are used for teaching and learning, lessons become more practical, interactive, interesting and real to pupils and students, and enables them to perform better in their academics.