This study investigated the use of computer-aided instruction (CAI) as an intervention for kindergarten students at risk for reading failure. Headsprout Early Reading (Headsprout 2005), a type of CAI, provides internet-based, reading instruction incorporating the critical components of reading instruction cited by the National Reading Panel (NRP 2000). A group of kindergarteners identified as at risk for reading failure based on fall Dynamic Indicators of Basic Early Literacy Skills (DIBELS) scores participated in Headsprout as a tier-one standard protocol, intervention within a response to intervention (RTI) process. The spring DIBELS scores of these students were compared with the scores of a matched group of kindergarten students who did not participate in CAI. Overall, kindergarteners who participated in CAI did not improve their reading performance significantly more than students who did not participate in CAI. Implications for practice and future research are discussed.