This paper is an analysis of published research on computer-assisted instruction (CAI) for mathematics involving students with learning disabilities. A systematic search of the literature on computer-assisted instructional interventions for students with learning disabilities yielded 25 studies that met the criteria for inclusion in this analysis. The studies were analyzed on an identified set of evidence-based instructional components validated in the effective teaching research. Overall, the results suggest that most of the identified evidence-based instructional components are incorporated into CAI programs used to teach mathematics to students with learning disabilities. Additionally, the results indicate that CAI is a generally effective means for increasing the mathematical performance of students with learning disabilities. Although promising, the implications for practice based on this analysis are limited by the relatively small number of studies reviewed and the diverse array of mathematical concepts and skills targeted. Findings from this analysis highlight the need for continued development and research validation of CAI programs focusing on improving learning outcomes of students with learning disabilities.