The integration of research and practice in social work education and agency practice is both complex and challenging. The analysis presented here builds upon the classic social work generalist framework (engagement, assessment, service planning and implementation, service evaluation, and termination) by developing a three-part framework to capture practice, research, and service user involvement. The article also includes a case vignette to illustrate the application of the framework. The evolution of practice-based research provides a venue for these integration issues, with special attention to the role played by service users. The analysis concludes with a series of questions to guide evolving practice and future research.