The research aims to develop "Sense of Life Meaning Scale" of Taiwan college students. In accordance with the related literature, most Western scholars adopted Frankl's Logotherapy for developing "Sense of Life Meaning Scale", which consists of freedom of will, will to meaning and meaning of life. The research also adopts these three beliefs as research factors; furthermore, with the related literature and measurements, 20-items questionnaire was designed. Owing to the past instrument have already proved the existence of three factors within sense of life meaning, CFA was directly applied for the research. This part is categorized into three models: (1) The initial model: the result reveals that two items' factor loadings are under 0.55., and need to be delete. (2) The modified model: After deleted two items, the model retested, and reveal firstly, the whole applicableness is acceptable; secondly, item quality test isn't under the situation of offending estimates (it means all output data are in an acceptable range); thirdly, internal construct applicableness analysis consisting of component reliability, average variance extracted; AVE (?v), competitive model comparison, and sex-group measurement identity test all qualified. (3) Cross-validity model: For the modified model, the research investigate another samples (N = 405), and after the re-verification, the outcome present acceptable whole applicableness. Therefore, the three factors 18 item scale of "Sense of Life Meaning" is built.