This study is designed to identify the most significant teaching methods that influence the acquisition of generic skills of mechanical engineering trades students at technical college level. Descriptive survey research design was utilized in carrying out the study. One hundred and ninety (190) respondents comprised of mechanical engineering trades' teachers and the administrators in the technical colleges in north central states of Nigeria responded to a structured questionnaire which addressed the research question. Based on the findings it was recommended that the technical college administrators must emphasize that teachers use the teaching methods identified from the result of the study as the most significant teaching method that influence the acquisition of generic skills in order for the students to acquire the skills for gainful employment in the labor market after graduation from the school.