The impact of alcohol and substance abuse on college students' behavior has become a ripe area of focus and research. However, interest and research has primarily been focused on traditional four- year college students. Thus, the four-year college experience is taken as the default against which two-year colleges are compared. Nearly 12 million students comprising some 45% of the collegiate population in the United States are in two-year colleges, with enrollment outpacing that of four-year schools. Given this reality, wherein two-year students represent an increasingly significant population, both numerically and in terms of their contribution to the economy, their invisibility in the literature on collegiate alcohol and substance use is remarkable. This paper addresses and highlights the deficiencies, disparities, and differences in alcohol and substance use on two-year and four-year college campuses as depicted by currently available research. Because the prevailing research specifically examines the extent to which use and/or abuse primarily exists on four-year campuses, the full magnitude of use on two-year campuses has been overlooked, minimized, and thus made invisible. We call for a new research agenda focused on two-year college campuses with the focus of discerning two-year college specific issues and programmatic concerns.