Engaging students in discussion and creating high impact teaching and learning practices are a challenge in every classroom. Small group discussion and poster presentations were used to solve case-based problems to highlight issues for the learner and to allow each student to demonstrate understanding and application of theory to real life examples through open-ended, focused questions. This study consisted of students enrolled in an Anatomy and Physiology course sequence. Assessment was based on group goal and individual accountability. Rubrics for evaluation were developed for self and peer assessment of each groups' dynamics. A poster session provided our students with an opportunity to explain their work to an audience, as well as generate active discussion and peer evaluations. This study showed a significant positive effect (p = 0.0001-0.0025) on students' knowledge, attitude and psychomotor skills.