The purpose of this research is to determine the relations between high school students' life satisfaction, burnout, work engagement and hopelessness scores and examine the contribution of their burnout, work engagement and hopelessness scores in the prediction of their life satisfaction scores. The Satisfaction with Life Scale (SWLS), Maslach Burnout Inventory--Student Survey (MBI-SS), Utrecht Work Engagement Scale--Student Survey (UWES-SS), Beck Hopelessness Scale (BHS) and "Personal Information Form", has been applied on a total of 461 students, 225 (%48.8) of them being girl students and 236 (%51.2) of them being male students, who were continuing the 12th grade in varying high school classes during the 2011-2012 school year within the provincial boundaries of the Mersin Municipality and had voluntarily accepted to participate in the research. Confirmatory factor analysis (CFA), correlation analysis and multiple regression analysis have been used in the analysis of the data. It is observed as a result of the analyses that high school students' life satisfaction scores have a negative relation with exhaustion, cynicism, efficacy and hopelessness scores; on the other hand, these have a positive relation with vigor, dedication and absorption scores. Also it has been observed that life satisfaction scores only predict hopelessness, absorption and efficacy in a meaningful way.