Since the passage of the Civil Rights Act of 1964, the retention of African American students at predominately White colleges and universities continues to be problematic. Although many of these institutions have implemented retention programs for African American students, few have incorporated a comprehensive program that utilizes multi-program components. Using a qualitative methodology, this study explored how a comprehensive retention program at one predominantly White university impacted the matriculation of African American students. The results revealed that the retention program had a positive influence on the success of African American students, thereby resulting in the students' receiving several academic, social, and cultural benefits. Also emerging from the study was a comprehensive retention model for supporting the retention of African American students at predominately White institutions.