The authors empirically examined whether the validity of a residualized dependent variable after covariance adjustment is comparable to that of the original variable of interest. When variance of a dependent variable is removed as a result of one or more covariates, the residual variance may not reflect the same meaning. Using the pretest-posttest design as a general framework, the authors compared the nomological validity network for the (a) original dependent variable scores and (b) residualized dependent variable scores after having covaried-out variance explainable by a pretest. Heuristic and empirical examples are provided that demonstrate potential variation in construct validity of residualized dependent variables is a function of correlations among dependent, covariate, and validity variables.