The purpose of this manuscript is to present a theoretical model of culture from which a conceptual framework has been built that can be used to conduct a cultural analysis. The paper presents definitions and components of culture and its role in our expanding global society. It then relates these to research findings related to the relationship between mentoring and culture. This information is used to create a cultural framework of mentoring which can be used to conduct a cultural analysis of the context in which a mentoring program exists in order to take actions that will aid in fostering its success. A model for using the framework in practice is presented.