This study explored differences between career decision-making self-efficacy (CDMSE) and career barriers of students enrolled in applied technology programs compared to those enrolled in college transfer. Participants in the ex post facto cross-sectional survey included 787 students at a community college. The following research questions were asked: (a) what is the predictive value of demographic variables on CDMSE and career barriers of applied technology and college transfer community college students? (b) is there a relationship between CDMSE and career barriers of applied technology and college transfer community college students? The Career Decision Self-Efficacy-Short Form and Career Barriers Inventory-Revised were administered to participants, and data were analyzed using two sample "t" tests, ANOVA and multiple regression models. There were significant differences between applied technology and college transfer students in terms of career barriers and career decision-making self-efficacy. Applied technology students, who tended to be older, had higher career decision-making self-efficacy scores than the college transfer students; this did not change across the other demographic variables. College transfer students, who tended to be younger, had higher perception of career barriers scores; this did not change across demographic variables. Future research is recommended to possibly gain specific information regarding demographics within these two groups. (Contains 4 tables.)