The Prevention and Intervention Programs for Children and Youth Who Are Neglected, Delinquent, or At-Risk, is authorized by Title I, Part D of the Elementary and Secondary Education Act of 1965 (ESEA) and was most recently amended in 2015 by the Every Student Succeeds Act (ESSA). This guidance is intended to be used in conjunction with the applicable statute and regulations, including the Education Department General Administrative Regulations (EDGAR) in 34 C.F.R. Part 76 and the Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (Uniform Guidance), 2 C.F.R. Part 200. All children and youth deserve the educational opportunities and supports they need to become the best version of themselves. This guidance is designed to assist States and subgrantees to make the most of Title I, Part D funds to enhance educational opportunities for children and youth who are neglected, delinquent, or at-risk, while connecting to and strengthening support systems that can provide a continuity of timeline and sufficient resources, services, and supports help these students succeed.