Psychological science has much to contribute to enhancing teaching and learning in the classroom. Teaching and learning are intricately linked to social and behavioral factors of human development, including cognition, motivation, social interaction, and communication. Psychological science can also provide key insights on effective instruction, classroom environments that promote learning, and appropriate use of assessment, including data, tests, and measurement, as well as research methods that inform practice. This report presents a supplement for use in the context of PreK-12 classroom teaching and learning, as well as the implications of each principle as applied to classroom practices for students with disabilities. Each principle is named and described, relevant supporting literature is provided, and its relevance for the special education students is discussed. This version of the principles is aimed at providing updated research explicit to special education students and relevance to teachers working with students with disabilities.