Background: The Centers for Disease Control and Prevention (CDC) identified Human Papillomavirus (HPV) as the most prevalent sexually transmitted infection (STI) in the United States, with approximately 24 million Americans currently infected. In 2018, men, ages 15-59, had higher HPV infection rates and HPV high-risk type infections compared to women of the same age range. The vaccine was approved for female use in 2007 to prevent HPV infections, but men did not receive approval to use the vaccine until 2011. HPV vaccination rates among men continue to be low. The purpose of this study aims to examine the racial disparities in Human papillomavirus (HPV) knowledge, behaviors, and norms and HPV vaccination intent among college men in Mississippi. Methods: A quantitative, cross-sectional epidemiological study evaluated men, ages 18 to 45, attending two public Mississippi universities. Surveys were disseminated via email through listserv and students' emails through public records requests. Results: One hundred ninety-one surveys were obtained, which was more significant than the sample size required by the power analysis. The results revealed that most Black and White college men heard of HPV but less heard about the HPV vaccine. The study showed no significant difference in HPV knowledge between the two groups, t (189) = 0.779, p = 0.437. However, there was a significant difference in HPV vaccine knowledge, t (189) = -4.284, p <0.001, with White men knowing more about the vaccine. The analysis revealed a significant difference between the two groups for subjective norm t (189) = 2.723, p = 0.007, and behavioral intention, t (189) = 4.395, p < 0.001. Attitude toward behavior, t (189) = 1.185, p = 0.071, and perceived behavioral control t (189) = 0.062, p = 0.951 were the constructs with no significant difference. The mean scores for most of the constructs were low, revealing a need for interventions to increase the intent to receive the vaccination. When investigating if there were significant differences in predictors between races, subjective norm, t = 5.794, p < 0.00, was a significant predictor for Black men. Attitude towards behavior, t = 3.053, p = 0.003, and subjective norm, t = 2.876, p = 0.005, were significant predictors for White men. Conclusion: Interventions for Black and White men should focus on increasing knowledge about HPV and HPV vaccine benefits, HPV infection risks, and avenues to receive the vaccine. Specifically focusing on vaccine safety for Black men. Also, incorporate an outreach that involves friends, family, and primary care providers' support for adult men to receive the vaccine series. Future research may implement a longitudinal study to utilize interventions to determine whether college men or men in that demographic initiate and complete the vaccine series. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]