Research has shown that while the number of school-age children has steadily increased over time, the number of qualified teachers available to educate them has not matched this need. This topical brief shows the percentage of public schools across the nation with teaching vacancies and summarizes strategies implemented in Region 5 Comprehensive Center (R5CC) (Kentucky, Tennessee, Virginia, and West Virginia) and Region 14 Comprehensive Center (R14CC) (Arkansas, Louisiana, and Texas) to address teacher shortages. This brief also provides examples of Comprehensive Center (CC) projects planned collaboratively with state education agency leaders to address teacher shortages.