Research on how to best meet the academic needs and potential of gifted students with disabilities, known as twice-exceptional or 2e, has grown over the past 30 years. While recognition of 2e learners is slowly extending to educational policy, there are few school program options designed to accommodate 2e students and even fewer studies on the organizational aspects of implementing such programs. This promising practice study sought to understand the organizational performance dynamics influencing teacher success in a school for 2e students through the lens of the Clark and Estes gap analysis framework. Data were collected using semi-structured interviews with middle-school teachers and a school administrator along with school documents and artifacts to ascertain the knowledge, motivation, and organizational assets contributing to success. The findings indicated that teacher performance was supported by knowledge of 2e characteristics, instructional strategies, and individual social-emotional competence. Teachers were motivated intrinsically and by self-efficacy. Organizational contributing factors were widespread transmission of the school's mission and vision, entrepreneurial mindset values, and identification with a shared purpose. The highly autonomy-oriented environment encouraged personal initiative and may have motivated teachers to seek learning resources independently. A teacher community of shared purpose developed, reinforcing collective knowledge and motivation systemically. Research-supported recommendations were made to address organizational challenges associated with cultivating successful 2e learning environments, followed by an implementation and evaluation plan guided by the New World Kirkpatrick Model. This study offers insight into key components influencing teacher performance within the dynamic and complex 2e learning environment. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]